3/12/2024 0 Comments Bakteri aerob dan anaerob pdfThree different conserved immunogenic regions were selected according to the selected criteria, and their various sequential orders were evaluated structurally by in silico tools to find the best order. Bioinformatics tools were then applied to predict and select epitopes for further studies. multocida were analyzed to identify the conserved regions. First, multiple alignments of different sequences of Pasteurella lipoprotein E (PlpE) from various serotypes of P. In this study, reverse vaccinology strategy was used to identify potentially immunogenic and protective epitopes. Therefore, the aim of this study was to reach a multi-epitope vaccine candidate that could be serotype independent and covers most incident serotypes of P. Current vaccines have certain disadvantages such as reactogenicity or reversion to virulence. Commercial vaccines against this agent include inactivated, live attenuated, and non-pathogenic bacteria. Humans can often be affected by cat scratch or bite, which may lead to soft tissue infections and in rare cases to bacteremia and septicemia. Pasteurella multocida is a Gram-negative, non-motile, non-spore forming, and aerobic/anaerobic cocobacillus known as the causative agent of human and animal diseases.
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